The Powerball drawing on Wednesday will give lottery players a shot at a jackpot of $422 million, which would rank as the nation's 11th largest lottery payout. Here's a look at the 10 largest U.S. jackpots and the winners' home states: 6. $564.1 million, Powerball, Feb. 11, 2015 (three tickets, from North Carolina, Puerto Rico and Texas)