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Bookmark or Share- Amylin structure–function relationships and receptor pharmacology ...Amylin is an important, but poorly understood, 37 amino acid glucoregulatory hormone with great potential to target metabolic diseases. A working example that the amylin system is one worth developing is the FDA‐approved drug used in insulin‐requiring diabetic patients, pramlintide.
- Mediators of Amylin Action in Metabolic Control - PMCAbstract. Amylin (also called islet amyloid polypeptide (IAPP)) is a pancreatic beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli. The last 35 years of intensive research have shown that amylin exerts important physiological effects on metabolic control.
- Amylin - an overview | ScienceDirect TopicsAmylin, also known as islet amyloid polypeptide (IAPP), is a 37-amino-acid hormone that is cosecreted with insulin from the pancreatic β-cells. Like insulin, amylin is to a certain extent tonically secreted into the circulation and its plasma concentration increases in
- Amylin Agonists: A Novel Approach in the Treatment of DiabetesAmylin is a peptide hormone that is cosecreted with insulin from the pancreatic β-cell and is thus deficient in diabetic people. It inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent. Amylin replacement could therefore possibly improve glycemic control in some people with diabetes.
- Human Amylin: From Pathology to Physiology and PharmacologyAmylin is an important hormone that is co-localized, copackaged, and co-secreted with insulin from islet β cells. Physiologically, amylin regulates glucose homeostasis by inhibiting insulin and glucagon secretion. Furthermore, amylin modulates satiety and inhibits gastric emptying via the central nervous system.
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