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BRCA Gene Mutations: Cancer Risk and Genetic Testing
BRCA1 and BRCA2 are sometimes called tumor suppressor genes because when they have certain changes, called harmful (or pathogenic) variants (or mutations), cancer can develop. People who inherit harmful variants in one of these genes have increased risks of several cancers—most notably breast and ovarian cancer, but also several additional ...
BRCA1 - Wikipedia
BRCA1 is a human tumor suppressor gene [7] [8] (also known as a caretaker gene) and is responsible for repairing DNA. [9] BRCA1 and BRCA2 are unrelated proteins, [10] but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired.
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks associated with BRCA1/BRCA2, screening, risk-reduction, treatment, and prognosis.
BRCA gene test for breast and ovarian cancer risk - Mayo Clinic
The BRCA gene test looks for DNA changes that increase the risk of breast cancer and ovarian cancer. BRCA1 and BRCA2 are the most well-known genes. Testing often looks for those genes and many other genes that increase the risk of breast and ovarian cancers.
BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer
BRCA1- and BRCA2- associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a B...
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