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Bookmark or Share- CD47: role in the immune system and application to cancer therapyBased on this observation, CD47 is currently considered as a prominent target in cancer therapy. Here, we review the role of CD47 in the maintenance of immune system homeostasis. We also depict three emerging CD47-targeting strategies for cancer therapy, including the use of mimicry peptides, antibodies, and gene silencing strategies.
- Structure of the human marker of self 5-transmembrane receptor CD47 ...CD47 is the only 5-transmembrane (5-TM) spanning receptor of the immune system. Its extracellular domain (ECD) is a cell surface marker of self that binds SIRPα and inhibits macrophage ...
- Role of CD47 in tumor immunity: a potential target for combination ...CD47 is a novel potent immunotherapy target in malignancies, targeting CD47 may be a novel strategy for cancer immunotherapy. A variety of studies have verified the synergistic effect of...
- Targeting CD47 for cancer immunotherapy - PMC - National Center for ...CD47-SIRPα blockade has emerged as a next-generation immune checkpoint disruption strategy in various malignancies after PD-1/PD-L1. Many CD47 monoclonal antibodies (mAbs) not only block CD47 from engaging SIRPα, but also engage the activating Fc gamma receptor (FcγR) on macrophages. Together they deliver a potent phagocytic signal to ...
- CD47 as a promising therapeutic target in oncology - PMCCD47 is a “don’t eat me” signal that plays a crucial role in erythrocytes homeostasis. Binding of CD47 to SIRPα generates an erythrocyte phagocytosis-associated deactivation of myosin IIA, which is a primary contributor to phagocytosis because of its participation in macrophage actinomyosin contraction.
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