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Oral Cavity and Oropharyngeal Cancer Stages
Oropharyngeal cancers that contain HPV DNA (called p16-positive) tend to have a better outlook than those without HPV (p16-negative). Because p16-positive cancers have a better prognosis than p16-negative oropharyngeal cancers, separate staging systems are used. Both systems are described below.
HPV-positive oropharyngeal cancer - Wikipedia
HPV is tested for by the presence of the biomarker p16, which normally increases in the presence of HPV. Some people can have elevated levels of p16 but test negative for HPV and vice versa. This is known as discordant cancer.
The Regulatory Mechanisms of Tumor Suppressor P16
Abstract. P16 INK4A (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin repeats, is recognized as a tumor suppressor mainly due to the prevalence of genetic inactivation of the p16INK4A (or CDKN2A) gene in virtually all types of human cancers.
p16 a biomarker of aging and tolerance for cancer therapy
This review describes the role of p16 in cell senescence, the methodology of p16 measurement in humans, preliminary studies of p16 in humans, and the potential clinical utility of p16 in guiding treatment for cancer patients. Keywords: p16, biomarker, senescence, cancer, aging.
Chronic expression of p16 - Nature
Abstract. p16 INK4a (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescence. Cells expressing p16 INK4a accumulate in aging tissues and appear in premalignant ...
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