NEW YORK (AP) — Stocks that moved substantially or traded heavily Tuesday on the New York Stock Exchange and the Nasdaq Stock Market: NYSE Novartis AG, up $3.43 to $93.47 The drug developer presented positive data for a potential heart-failure drug and will ask for approval by the end of the year. Las Vegas Sands Corp., down $3.41 to $63.10 The casino operator and its gambling company peers experienced a decline in revenue from the gambling hub Macau during August. Cloud Peak Energy Inc., down $1.27 to $14.44 The coal company lowered its coal shipment and adjusted earnings guidance for 2014, citing rail issues and weather impacts. Crown Holdings Inc., up $1.85 to $50.12 The packaging products company is buying the Mexican can packaging business of brewer Heineken for just under $1.23 billion. Nasdaq Exelixis Inc., down $2.29 to $1.85 The biotechnology company said its potential treatment for prostate cancer failed to meet a key goal in a late-stage study. Conns Inc., down $13.83 to $31 The consumer goods retailer reported second-quarter profit below Wall Street expectations and cut its full-year profit guidance. Norwegian Cruise Line Holdings Ltd., up $3.68 to $36.99 The cruise line will buy Prestige Cruises International for about $3 billion and expects to close the deal in the fourth quarter. Acadia Pharmaceuticals Inc., up $2.63 to $26.61 The biotechnology company received a special FDA designation for its potential Parkinson's disease psychosis treatment, Nuplazid.Read more on NewsOK.com