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Republican Sen. Rand Paul said Tuesday that illegal immigrants should be allowed to become U.S. taxpayers and ultimately get a shot at citizenship, a significant step for the Tea Party favorite amid growing Republican acceptance of the idea.

Republican U.S. Sen. Rob Portman is now supporting gay marriage and says his reversal on the issue began when he learned one of his sons is gay. Ohio's junior senator disclosed his change of heart in interviews with several Ohio newspapers and CNN. In an op-ed published Friday in The Columbus Dispatch, he said the decision came after a lot of thought.

Florida Sen. Marco Rubio says Republican Mitt Romney will win the White House, but not with Rubio on the ticket.

With less than a week to go before Iowa caucuses, former Pennsylvania senator's strategy of traveling widely in the state appears to be paying dividends, as he shows up in polls as a top-tier candidate.

Arizona’s Sen. John McCain (R) said illegal immigrants may have started some of the wildfires that have forced thousands of people from their homes in his state, but he did not give evidence to support the statement.

Sen. John McCain, the Republican presidential candidate in 2008, took aim Sunday at the field of contenders for the 2012 GOP nomination, accusing them of "isolationism." "We cannot repeat the lessons of the 1930s, when the United States of America stood by while bad things happened in the world," McCain said in an interview with ABC's "This Week."

Former Pennsylvania Sen. Rick Santorum, once the No. 3 Republican in the Senate, said Monday he's seeking the GOP nomination for president to protect American freedoms under threat from President Barack Obama.

Former Pennsylvania Sen. Rick Santorum is expected to make his 2012 run for the White House official June 6th at the Somerset County Courthouse in southwest Pennsylvania.

Embattled Republican Sen. John Ensign of Nevada announced Thursday that he will resign amid an ongoing ethics investigation, a move that could spare him from the continued embarrassment of the closely watched probe....

Sen. John Thune of South Dakota ends speculation about his candidacy. Potential Republican candidates have been hesitant to launch formal campaigns as early as in past cycles.