ANN ARBOR, Mich. >> Michigan athletic director Dave Brandon's resignation officially takes effect Saturday.The Wolverines host Indiana in their homecoming football game that day - and if they lose that one, it would be yet another low point this season.The Wolverines have won 18 straight games against the Hoosiers and 33 of the last 34 in the series, a run of dominance that has withstood the downturn in Michigan's fortunes in recent years.