The 49ers received a 2018 seventh-round pick, according to ESPN.
After spending his first NFL season on injured reserve with a foot injury, Acker had three interceptions in 13 starts last year.
Acker is the third player the 49ers have dealt to Kansas City since 2013, joining quarterback Alex Smith and wide receiver A.
Melvin Upton Jr. hit an RBI triple and continued home on a misplay in the eighth inning, completing Toronto's rally from a five-run deficit and sending the AL East-leading Blue Jays over the Minnesota Twins 8-7 Saturday.
Edwin Encarnacion homered and drove in three runs as Toronto handed the Twins their ninth straight loss.
The Blue Jays trailed 7-6 in the eighth when Kevin Pillar doubled with one out off Ryan Pressly (6-6).
Alex Smith was sharp in leading three scoring drives in the first half and the Kansas City Chiefs got a 23-7 preseason victory over the Chicago Bears on Saturday.
Smith completed 20 of 30 passes for 181 yards before Nick Foles came in to start the third quarter.
Olympic champion Ruth Jebet broke the women's 3,000-meter steeplechase world record by six seconds at the Diamond League meeting in Paris on Saturday.
The 19-year-old Jebet, born in Kenya but running for Bahrain, clocked 8 minutes, 52.78 seconds at Stade de France.
The previous record was 8:58.81 by Gulnara Samitova-Galkina of Russia at the 2008 Beijing Games.
Tennessee coach Butch Jones has a different kind of team this season.
According to some players, that's allowing him to be a different type of coach.
Jones spent the first few years of his Tennessee tenure attempting to restock the talent base and instill a winning culture.