MINNEAPOLIS — Nelson Cruz’s towering two-run home run seemed to give the Seattle Mariners the jolt they needed Saturday night, tying the score with the second-longest homer in the majors this season. Instead, Minnesota’s own big slugger, Miguel Sano, responded with his own big swing and a big defensive play after an error in the ninth inning to keep Seattle’s struggling offense down and deal a blow to the Mariners’ wild-card hopes. Sano hit a tiebreaking homer in the fourth inning and Tyler Duffey pitched seven strong innings for his best start in more than a month as the Twins beat Seattle 3-2 on Saturday night. “They hit a big homer there,” Sano said.