European markets are in the red early Wednesday. Here's the scorecard: Britain's FTSE 100 is down 0.20%. France's CAC 40 is down 0.51%. Germany's DAX is down 0.11%. Spain's IBEX is up 0.28%. Italy's FTSE MIB is down 0.10%. The comes after the U.S. and Europe imposed the toughest sanctions against Russia since the cold war for its involvement in Ukraine.