NEW YORK (AP) — Rafael Nadal had never lost a Grand Slam match when taking a two-set lead until he was beaten 3-6, 4-6, 6-4, 6-3, 6-4 by 32nd-seeded Fabio Fognini of Italy in the third round of the U.S. Open on Friday night.The eighth-seeded Nadal's defeat also ends the Spaniard's 10-year streak of winning at least one major title per season.