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Bookmark or Share- C1q: A fresh look upon an old molecule - PMC - National Center for ...C1q is a complex glycoprotein assembled from 18 polypeptide chains, with a C-terminal globular head region that mediates recognition of diverse molecular structures, and an N-terminal collagen-like tail that mediates immune effector mechanisms.
- Complement component 1q - WikipediaThe complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the C1 complex. Antibodies of the adaptive immune system can bind antigen, forming an antigen-antibody complex.
- Understanding the contextual functions of C1q and LAIR-1 and their ...This review describes the fundamental roles of C1q in various microenvironments and focuses on the importance of the interactions of C1q and its receptors with the inhibitory receptor LAIR-1 in...
- Emerging Roles of Complement Protein C1q in NeurodegenerationC1q, which modulates the immune responses of a variety of cells, is also produced by cells of the central nervous system (CNS). In the CNS, C1q plays a role in synaptic pruning during CNS development process . C1q also has a broad neuroprotective role during the inflammatory response to pathogens.
- C1q: Its Functions within the Innate and Adaptive Immune Responses and ...C1q is the recognition component of the classical pathway of complement activation. In addition, C1q has been recognized to serve a number of other biological functions including a modulating role on cellular functions within the adaptive immune response.
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