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Bookmark or Share- CD3: Structure, function, and role of immunostaining in ...Corresponding Author. Runjan Chetty. Dr. University Department of Cellular Science, University of Oxford, Oxford, U.K. University Department of Cellular Science, University of Oxford, Level 4, Academic Block, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K.Search for more papers by this author
- Modulating T Cell Responses by Targeting CD3 - PMCIn this review, we summarize the basis of CD3–TCR complex assembly and survey the clinical and preclinical therapeutic tools available to modulate CD3–TCR function for potentiating cancer immunotherapy. Keywords: CD3, TCR, T cell engager, cancer immunotherapy, T cell modulation, antibodies, aptamers. Go to: 1.
- CD3 (immunology) - WikipediaCD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
- Overcoming the challenges associated with CD3+ T-cell ...The development of novel CD3+ T-cell redirectors with the ability to target two tumour antigens is a potential strategy that can be used to overcome tumour antigen escape and restore anti-tumour...
- CD3-specific antibodies: a portal to the treatment of ...CD3-specific monoclonal antibodies have great potential as therapeutics for autoimmune diseases through the induction of immune tolerance. This Review discusses the current progress of the use...
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