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Bookmark or Share- Uncoupling FoxO3A mitochondrial and nuclear functions in ... - NatureElucidation of FoxO3A mitochondrial vs. nuclear functions in cancer cell homeostasis might help devise novel therapeutic strategies to selectively disable FoxO3A prosurvival activity.
- FOXO family isoforms | Cell Death & Disease - NatureAnother recent study identified FOXO3A-Short (FOXO3A-S), a primate-specific FOXO3A transcriptional isoform encoding a major longevity-associated SNP within its 5′-untranslated region ....
- Critical role of FOXO3a in carcinogenesis - Molecular CancerEmerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer.
- FOXO3 - WikipediaIt is thought that FOXO3a is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD. Ron DePinho 's group generated Foxo3 knockout mice, and showed that female exhibit a dramatic age-dependent infertility, due to premature ovarian failure.
- FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular ...The transcription factor Forkhead box protein O3 (FOXO3a) is a core regulator of cellular homeostasis, stress response, and longevity since it can modulate a variety of stress responses upon nutrient shortage, oxidative stress, hypoxia, heat shock, and DNA damage.
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