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Bookmark or Share- IL-12 and IL-23 cytokines: from discovery to targeted ... - NatureNature Medicine - Cua and colleagues discuss the cellular and molecular rationale for targeting IL-12 and IL-23 for therapeutic purposes in inflammatory diseases; they also review existing clinical...
- Immunology of IL-12: An update on functional activities and ...Taken together, undoubtedly, IL-12 as well as IL-23 are implicated in the pathogenesis of IBD. Hence, they are promising targets for IBD therapy, which has further been supported by observations in IBD patients. IL-12 transcription is increased in both subtypes of IBD (Nemeth et al., 2017 [ 137 ]).
- Interleukin 12 - WikipediaSwiss-model. Domains. InterPro. Interleukin 12 ( IL-12) is an interleukin that is naturally produced by dendritic cells, [1] macrophages, neutrophils, helper T cells and human B- lymphoblastoid cells ( NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12.
- Re-designing Interleukin-12 to enhance its safety and ... - NatureThese findings offer renewed hope for development of IL-12-based treatments for cancer. Interleukin-12 (IL-12) is a potent immunotherapeutic agent.
- Interleukin-12: an update on its immunological activities, signaling ...Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It is produced by antigen-presenting cells and plays a critical role in host defense against intracellular microbial infection and control of malignancy via its ability to stimulate both innate and adaptive immune effector cells.
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