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Bookmark or Share- Interleukin-6: A Masterplayer in the Cytokine Network - PubMedInterleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.
- IL-6 as a keystone cytokine in health and disease - NatureNature Immunology - IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. Hunter and Jones discuss the effect of...
- IL-6 in inflammation, autoimmunity and cancer - PMCIL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely related to chronic inflammatory diseases, autoimmune diseases and cancer) and even in the cytokine storm of corona virus disease 2019 (COVID-19).
- IL-6 in Inflammation, Immunity, and Disease - PMC - National Center for ...IL-6 is a cytokine featuring pleiotropic activity; it induces synthesis of acute phase proteins such as CRP, serum amyloid A, fibrinogen, and hepcidin in hepatocytes, whereas it inhibits production of albumin. IL-6 also plays an important role on acquired immune response by stimulation of antibody production and of effector T-cell development.
- Interleukin-6 signalling in health and disease - PMCInterleukin-6 (IL-6) is considered one of the most prominent pro-inflammatory cytokines 1. Blockade of IL-6 by the neutralising monoclonal antibody tocilizumab has been approved in more than 100 countries for the treatment of patients with autoimmune disorders such as rheumatoid arthritis 2.
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