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MEN1 - Wikipedia
Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. Variations in the MEN1 gene can cause pituitary adenomas, hyperparathyroidism, pancreatic neuroendocrine tumors, gastrinoma, and adrenocortical cancers.
Menin: a scaffold protein that controls gene expression and cell ...
The crystal structures of menin with different binding partners reveal that menin is a key scaffold protein that functionally crosstalks with various partners to regulate gene transcription and interplay with multiple signaling pathways. Keywords: cell signaling; gene transcription; menin; scaffold protein. Copyright © 2013 Elsevier Ltd.
Targeting menin: a promising therapeutic strategy for ... - Nature
Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes | Signal Transduction and Targeted Therapy. Research Highlight. Open access. Published: 11 October 2023....
MEN1 mutations mediate clinical resistance to menin inhibition
In a phase 1 first-in-human clinical trial, the menin inhibitor revumenib, which is designed to disrupt the menin–MLL1 interaction, induced clinical responses in patients with leukaemia with...
MEN1 Gene - GeneCards | MEN1 Protein | MEN1 Antibody
MEN1 Gene - Menin 1. Protein Coding (Updated: Apr 3, 2024 ; GC11M064803 ; GIFtS: 54 ) Search in Gene. Follow Gene. Jump to section. Aliases. Disorders. Domains. Drugs. Expression. Function. Genomics. Localization. Orthologs. Paralogs. Pathways. Products. Proteins. Publications. Sources. Summaries. Transcripts. Variants.
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