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Bookmark or Share- Dissecting OCT4 defines the role of nucleosome binding in ... - NatureNature Communications (2023) Pioneer transcription factors such as OCT4 can target silent genes embedded in nucleosome-dense regions. How nucleosome interaction enables transcription factors to ...
- OCT4 (Octamer-Binding Transcription Factor 4) | SpringerLinkOCT4 is a member of the class 5 POU (Pit-Oct-Unc) family of homeodomain transcription factors. It is so named because of its specific binding to the canonical octamer motif (with consensus sequence ATGCA/TAAT) at target gene promoter or enhancer regions.
- Oct-4 - WikipediaOct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded by the POU5F1 gene. Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells.
- Stem cell pluripotency and transcription factor Oct4In this review, we summarize the structure and function of Oct4 and address issues related to Oct4 function in maintaining totipotency or pluripotency of embryonic stem cells.
- A balanced Oct4 interactome is crucial for maintaining pluripotency - AAASAbstract. Oct4 collaborates primarily with other transcriptional factors or coregulators to maintain pluripotency. However, how Oct4 exerts its function is still unclear. Here, we show that the Oct4 linker interface mediates competing yet balanced Oct4 protein interactions that are crucial for maintaining pluripotency.
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