Oprah Winfrey will return to acting, headlining HBO Films’ The Immortal Life of Henrietta LacksEmmy winner and Oscar nominee Oprah Winfrey (Selma, The Color Purple) will star in HBO Films’ The Immortal Life of Henrietta Lacks, based on Rebecca Skloot’s acclaimed bestselling nonfiction book of the same name. DGA winner, Emmy nominee and veteran Broadway director-producer George C.