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Sen. Arlen Specter suggests that one of the reasons he left the GOP was because it did not share his interest in funding medical research.

The moderate Pennsylvania senator says the GOP 'has moved far to the right.' The move means that Democrats will likely be able to block any Senate filibuster.

Key strategist urges GOP to shift position or risk losing voters who are young or live outside South.

Majority Leader Harry Reid indicated Wednesday he's willing to move sweeping health care legislation through the Senate with a procedural maneuver that would block a GOP filibuster. The prospect of the controversial tactic has already ignited Republicans' ire, and key Senate Democratic chairmen have said they don't want to do it.

The new chairman of the Republican party walks back remarks he made about the popular conservative radio host, whose broadcasts have prompted Democrats to try to link him to the leadership of the G.O.P.

Top Republican lawmakers today called on President Obama to change his political strategy, arguing that the passage of a massive stimulus bill on a party-line vote showed he has failed to deliver the "change" he promised. Sen. John McCain told CNN's "State of the Union With John King" that the president was off to "a bad beginning." Sen. Lindsay Graham was blunter: "If this is going to be bipartisanship, the country's screwed."

There would be no change in the Senate's balance of power if New Hampshire Republican Judd Gregg leaves to become commerce secretary, says the Senate's top Republican, Mitch McConnell.

Limbaugh's caustic comments have one of the House's leading conservatives defending colleagues.