As we get older, our heart, the muscle that keeps our blood pumping, changes dramatically — and a recent study finds that much of the change often falls along gender lines. The long-term study looked at 5,000 participants aged 45-84 over a 10-year period who were taking part in the Multi-Ethnic Study of Atherosclerosis, a study sponsored by the National Institute of Health’s National Heart Lung and Blood Institute.

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